Efficacy of single dose Acyclovir in the treatment of chronic periodontitis – A Pilot study

Tabatabaee sepehr, Khosropanah H, Rasoli M, Vasegh K, Khzam N, Roy George


Background: Periodontitis is a common, chronic and progressive disease affect majority of the population. Current evidence indicates that Porphyromonas gingivalis is one of the most common pathogens isolated in patients with periodontitis. Aims and Objectives: To compare the clinical parameters and presence of P. gingivalis following a single subgingival application of 2.5% acyclovir gel combined with Scaling and Root Planing (SRP) or SRP alone. Materials and Methods: Healthy patients (10 females; 10 males) diagnosed with moderate to severe chronic periodontitis received manual SRP and oral hygiene instructions before random assignment into intervention (2.5% acyclovir gel + SRP) and control (SRP) groups. Clinical parameters (periodontal pocket depth, clinical attachment level, and bleeding on probing) were recorded and subgingival plaque sampling performed before treatment and after one and three months. Results: There was a significant reduction in P. gingivalis count and the mean PPD between the baseline and at first and third months post-therapy for both groups, but no difference between the two groups. There was a significant decrease in CAL at each time point in the intervention group as compared with control. Conclusions: SRP with or without a single application of 2.5% acyclovir gel improves clinical parameters and reduce P. gingivalis count for patients with chronic periodontitis.


Acyclovir; Chronic Periodontitis; Root Planing; Scaling


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