Efficacy of topical application of 4-aminomethyl-benzoic acid among extraction patients taking warfarin
Aims and Objectives: To evaluate the effect of topical Application of 4-Aminomethyl- Benzoic Acid (4-ABA) in Homeostasis of the bleeding after atraumatic tooth extraction in patients taking warfarin. Materials and Methods: Fifty patients, 30 males and 20 females with mean age of 66 years using warfarin with an INR ≤3.5 were included in this study. After teeth extraction the sockets in 25 patients are dressed with a gauze saturated with 4-Aminomethyl- Benzoic Acid for thirty minutes (group A) while the others are covered with dry dress and served as control (group B). Bleeding from the extraction site is evaluated and considered mild if it lasts less than ten minutes, moderate if it lasts between ten and twenty minutes and severe if it lasts more than twenty minutes. P-value of less than 0.05 is considered significant. Results: All patients in group A had mild bleeding, while 88% of patients in group B had moderate bleeding and two patients underwent severe bleeding and returned to the clinic where they received local measures to control bleeding. The results show that the value of PHI and CRAMER tests is close to the correct one, indicating the strength of correlation between the variables as the value of these coefficients significant (Sig = 0.00.). Conclusion: Topical Application of 4-Aminomethyl- Benzoic Acid after teeth extraction in patients taking warfarin is effective in achieving Homeostasis.
Abdullah WA, Khalil H. Dental extraction in patients on warfarin treatment. Clin Cosmet Investig Dent. 2014;6:65-9.
Linnebur SA, Ellis SL, Astroth JD. Educational practices regarding anticoagulation and dental procedures in US dental schools. Journal of dental education. 2007;71(2):296-303.
Lim W, Wang M, Crowther M, Douketis J. The management of anticoagulated patients requiring dental extraction: a cross‐sectional survey of oral and maxillofacial surgeons and hematologists. Journal of Thrombosis and Haemostasis. 2007;5(10):2157-9.
Madhulaxmi M, Wahab A. Can aspirin be continued during dental extraction. International Journal of Pharmacy and Pharmaceutical Sciences. 2014;6(1):20-3.
Devani P, Lavery K, Howell C. Dental extractions in patients on warfarin: is alteration of anticoagulant regime necessary? British Journal of Oral and Maxillofacial Surgery. 1998;36(2):107-11.
DeLoughery TG. Hemostasis and thrombosis: Springer; 1999.
Sindet-Pedersen S. Haemostasis in oral surgery--the possible pathogenetic implications of oral fibrinolysis on bleeding. Experimental and clinical studies of the haemostatic balance in the oral cavity, with particular reference to patients with acquired and congenital defects of the coagulation system. Danish medical bulletin. 1991;38(6):427-43.
Majerus P, Dalcette B, Hermans M, Pourtois M, Capel P. Variations in fibrinolytic activity of human whole saliva. European journal of oral sciences. 1996;104(4):341-5.
Bacci C, Maglione M, Favero L, Perini A, Di Lenarda R, Berengo M, et al. Management of patients undergoing anticoagulant treatment. Thrombosis and haemostasis. 2010;104(2010):104-5.
Snipelisky D, Kusumoto F. Current strategies to minimize the bleeding risk of warfarin. J Blood Med. 2013;4:89-99.
Jaffer AK, Brotman DJ, Chukwumerije N. When patients on warfarin need surgery. Cleveland clinic journal of medicine. 2003;70(11):973-84.
Brewer AK. Continuing warfarin therapy does not increased risk of bleeding for patients undergoing minor dental procedures. Evidence-based dentistry. 2009;10(2):52.
Nematullah A, Alabousi A, Blanas N, Douketis JD, Sutherland SE. Dental surgery for patients on anticoagulant therapy with warfarin: a systematic review and meta-analysis. J Can Dent Assoc [Internet]. 2009; 75(1):[41a-h pp.]. Available from: http://www.cda-adc.ca/jcda/vol-75/issue-1/41.html.
Randall C. Surgical management of the primary care dental patient on warfarin. Dental update. 2005;32(7):414-6, 9-20, 23-4.
Meredith D, Boyd C, Bronk J, Bailey P, Morgan K, Collier I, et al. 4‐Aminomethylbenzoic acid is a non‐translocated competitive inhibitor of the epithelial peptide transporter PepT1. The Journal of physiology. 1998;512(3):629-34.
Hong C, Napenas JJ, Brennan M, Furney S, Lockhart P. Risk of postoperative bleeding after dental procedures in patients on warfarin: a retrospective study. Oral surgery, oral medicine, oral pathology and oral radiology. 2012;114(4):464-8.
Scully C, Wolff A. Oral surgery in patients on anticoagulant therapy. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology. 2002;94(1):57-64.
Peterson L, Ellis E, Hupp J, Tucker M. Contemporary oral and maxillofacial surgery. 3rd ed. St. Louis: MO: C.V. Mosby; 1998.
Dinkova A, Kirova D, Delev D. Management of patients on anti-coagulant therapy undergoing dental surgical procedures. Review Article. World Health. 2013;12(13):14.
Baykul T, Alanoglu E, Kocer G. Use of Ankaferd Blood Stopper as a hemostatic agent: a clinical experience. J Contemp Dent Pract. 2010;11(1):E088-94.
Pereira CM, Gasparetto PF, Carneiro DS, Corrêa MEP, Souza CA. Tooth extraction in patients on oral anticoagulants: prospective study conducted in 108 brazilian patients. International Scholarly Research Network ISRN Dentistry. 2011:1-4.
Scopp IW, Fredrics H. Dental extractions in patients undergoing anticoagulant therapy. Oral Surgery, Oral Medicine, Oral Pathology. 1958;11(5):470-4.
Blinder D, Manor Y, Martinowitz U, Taicher S. Dental extractions in patients maintained on continued oral anticoagulant: comparison of local hemostatic modalities. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology. 1999;88(2):137-40.
Evans I, Sayers M, Gibbons A, Price G, Snooks H, Sugar A. Can warfarin be continued during dental extraction? Results of a randomized controlled trial. British Journal of Oral and Maxillofacial Surgery. 2002;40(3):248-52.
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