Therapeutic effect of topical subgingival application of 1.5% chlorhexidine gel as local drug delivery system in chronic periodontitis – a clinical and microbiological study
Aims and Objectives: To evaluate therapeutic effect of topical subgingival application of 1.5% Chlorhexidine gel as local drug delivery system in chronic periodontitis. Materials and Method: The study sample consists of 30 subjects of both the gender suffering from chronic periodontitis. Clinical parameters like Plaque index, Gingival index, Sulcus Bleeding Index, relative attachment level, probing pocket depth and subgingival plaque samples were taken and anaerobic culturing was done at baseline and then at 30 days after therapy. Scaling and root planing was performed in all teeth. Selected sites were then assigned to different treatment modalities as experimental site (Scaling and root planing plus 1.5% chlorhexidine gel) and control site (Scaling and root planing only). Bacteria were identified based on their morphotype and were divided into two groups: Gram-positive cocci and Gram negative bacilli. Results: After 30 days there was significant reduction in percentage of anaerobic gram-negative bacilli and relative increase in percentage of gram-positive cocci in the experimental group. Statistically significant reduction in Plaque Index, Gingival Index, Sulcus Bleeding Index (p<0.001), Probing Pocket Depth and significant gain in Relative Attachment Level were noticed for experimental site as compared to control site. Conclusion: This study concludes that 1.5% chlorhexidine gel as an adjunct to scaling and root planing is found to be more effective in reducing plaque, gingival inflammation and pocket depth and gain in clinical attachment level when compared to scaling and root planing alone.
Jain M, Dave D, Jain P, Manohar B, Yadav B, Shetty N. Efficacy of xanthan based chlorhexidine gel as an adjunct to scaling and root planing in treatment of the chronic periodontitis. Journal of Indian Society of Periodontology. 2013;17(4):439-43.
Behal R, Mali AM, Gilda SS, Paradkar AR. Evaluation of local drug-delivery system containing 2% whole turmeric gel used as an adjunct to scaling and root planing in chronic periodontitis: A clinical and microbiological study. Journal of Indian society of Periodontology. 2011;15(1):35-8.
Nair SC, Anoop K. Intraperiodontal pocket: An ideal route for local antimicrobial drug delivery. Journal of advanced pharmaceutical technology & research. 2012;3(1):9-15.
Tariq M, Iqbal Z, Ali J, Baboota S, Talegaonkar S, Ahmad Z, et al. Treatment modalities and evaluation models for periodontitis. International journal of pharmaceutical investigation. 2012;2(3):106-22.
Pragati S, Ashok S, Kuldeep S. Recent advances in periodontal drug delivery systems. International Journal of Drug Delivery. 2011;1(1):1-14.
Chhina K, Bhatnagar R. Local Drug Delivery. Indian Journal of Dental Sciences. 2012;4(1).
Divya P, Nandakumar K. Local Drug Delivery—Periocol In Periodontics. Trends Biomater Artif Organs. 2006;19(2):74-80.
Dodwad D, Vaish S, Mahajan A, Chhokra M. Local drug delivery in periodontics: a strategic intervention. International Journal of Pharmacy and Pharmaceutical Sciences. 2012;4(4):30-4.
Francis J, Hunter B, Addy M. A Comparison of Three Delivery Methods of Chlorhexidine in Handicapped Children: I. Effects on Plaque, Gingivitis, and Toothstaining. Journal of periodontology. 1987;58(7):451-5.
Mundinamane DB, Venkataraghavan K, Garg A. Newer trends in local drug delivery for periodontal problems–A preview. International Journal of Contemporary Dentistry. 2011;2(4).
Pitcher G, Newman H, Strahan J. Access to subgingival plaque by disclosing agents using mouthrinsing and direct irrigation. Journal of clinical periodontology. 1980;7(4):300-8.
Rosling B, Slots J, Christersson LA, Gröndahl H, Genco R. Topical antimicrobial therapy and diagnosis of subgingival bacteria in the management of inflammatory periodontal disease. Journal of clinical periodontology. 1986;13(10):975-81.
Sadaf N, Anoop B, Dakshina B, Shweta B. Evaluation of efficacy of tetracycline fibers in conjunction with scaling and root planing in patients with chronic periodontitis. Journal of Indian Society of Periodontology. 2012;16(3):392-4.
Shiloah J, Hovious LA. The role of subgingival irrigations in the treatment of periodontitis. Journal of periodontology. 1993;64(9):835-43.
Grisi DC, Salvador SL, Figueiredo LC, Souza SL, Novaes AB, Grisi MF. Effect of a controlled‐release chlorhexidine chip on clinical and microbiological parameters of periodontal syndrome. Journal of clinical periodontology. 2002;29(10):875-81.
Vinholis A, Figueiredo L, Marcantonio Júnior E, Marcantonio R, Salvador S, Goissis G. Subgingival utilization of a 1% chlorhexidine collagen gel for the treatment of periodontal pockets. A clinical and microbiological study. Braz Dent J. 2001;12(3):209-13.
Pannuti C, Saraiva M, Ferraro A, Falsi D, Cai S, Lotufo R. Efficacy of a 0.5% chlorhexidine gel on the control of gingivitis in Brazilian mentally handicapped patients. Journal of clinical periodontology. 2003;30(6):573-6.
Perinetti G, Paolantonio M, Cordella C, D’ercole S, Serra E, Piccolomini R. Clinical and microbiological effects of subgingival administration of two active gels on persistent pockets of chronic periodontitis patients. Journal of clinical periodontology. 2004;31(4):282-5.
Turesky S, Gilmore ND, Glickman I. Reduced plaque formation by the chloromethyl analogue of victamine C. Journal of periodontology. 1970;41(1):41-3.
Löe H. The gingival index, the plaque index and the retention index systems. Journal of periodontology. 1967;38(6):610-6.
Mühlemann H, Son S. Gingival sulcus bleeding--a leading symptom in initial gingivitis. Helvetica odontologica acta. 1971;15(2):107113.
Badersten A, Nilvéus R, Egelberg J. Effect of nonsurgical periodontal therapy. Journal of clinical periodontology. 1981;8(1):57-72.
Soskolne W, Heasman P, Stabholz A, Smart G, Palmer M, Flashner M, et al. Sustained local delivery of chlorhexidine in the treatment of periodontitis: a multi-center study. Journal of periodontology. 1997;68(1):32-8.
Goodson JM, Palys MD, Carpino E, Regan EO, Sweeney M, Socransky SS. Microbiological changes associated with dental prophylaxis. Journal of the American Dental Association (1939). 2004;135(11):1559-64; quiz 622-3.
Slots J. Subgingival microflora and periodontal disease. Journal of Clinical Periodontology. 1979;6(5):351-82.
Quirynen M, Mongardini C, Pauwels M, Bollen CM, Eldere JV, Steenberghe DV. One stage full-versus partial-mouth disinfection in the treatment of chronic adult or generalized early-onset periodontitis. II. Long-term impact on microbial load. Journal of Periodontology. 1999;70(6):646-56.
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