Siddana Goud Reddy, Shoba Fernandes, Shrudha Potdar, Kailash Attur


Throughout the various discoveries in Medical sciences progress has been achieved at some cost. Side-effects of allopathic medications are one such situation. Renewed research into various plant products is currently in progress. This short review endeavors to bring about an understanding regarding the various applications of plant products in oral health care.


Oral health;Onion;Ginger;Garlic; Aloevera;Turmeric;Plant products


Greenwald J. Herbal healing. Time1998;23;58-69.

Slifman NR, Obermeyer WR, Aloi BK, et al. Contamination of botanical dietary supplements by Digitalis lanata. N EngI J Med1998;339:806-81.

Ernst E. Harmless herbs? A review of the recent literature. Am J Med1998; 104:170-178.

Kim JH. Anti-bacterial action of onion (Allium cepa L.) extracts against oral pathogenic bacteria. J Nihon Univ Sch Dent1997 ;39(3):136-41.

Ernst E. The role of complementary and alternative medicine in cancer. Lancet Oncol 2000;1:176–80.

Izzo AA, Capasso R, Capasso F. Eating garlic and onion: a matter of life or death. Br J Cancer2004;91:194.

Shirin H, Pinto JT, Kawabata Y, et al. Antiproliferative effects of S-allylmercaptocysteine on colon cancer cells when tested alone or in combination with sulindac sulfide. Cancer Res2001;61:725–31.

Xiao D, Pinto JT, Gundersen GG, Weinstein IB. Effects of a series of organosulfur compounds on mitotic arrest and induction of apoptosis in colon cancer cells. Mol Cancer Ther2005;4:1388 –98.

Yang J, Meyers KJ, van der Heide J, Liu RH. Varietal differences in phenolic content and antioxidant and antiproliferative activities of onions. J Agric Food Chem 2004;52:6787–93.

Yang CS, Chhabra SK, Hong JY, Smith TJ. Mechanisms of inhibition of chemical toxicity and carcinogenesis by diallyl sulfide (DAS) and related compounds from garlic. J Nutr 2001;131:1041S–5S.

Chavan SD, Shetty NL, Kanuri M. Comparative evaluation of garlic extract mouthwash and chlorhexidine mouthwash on salivary Streptococcus mutans count - an in vitro study. Oral Health Prev Dent 2010;8(4):369-74.

Bachrach G, Jamil A, Naor R, Tal G, Ludmer Z, Steinberg D. Garlic Allicin as a Potential Agent for Controlling Oral Pathogens. J Med Food. 2011:6.

Groppo FC, Ramacciato JC, Motta RH, Ferraresi PM, Sartoratto A. Antimicrobial activity of garlic against oral streptococci. Int J Dent Hyg2007;5(2):109-15.

Knowles LM, Milner JA. Possible mechanism by which allyl sulfides suppress neoplastic cell proliferation. J Nutr2003;131: 1061S–1066S.

Griffiths G, Trueman L, Crowther T, Thomas B, Smith B. Onions. A global benefit to health. Phytother Res2002;16: 603–615.

Rahman K (2003) Garlic and aging: new insights into an old remedy. Ageing Res Rev 2: 39–56.

Thomson M, Ali M.Garlic (Allium sativum): a review of its potential use as an anti-cancer agent. Curr Cancer Drug Targets;2003:3: 67– 8.

AA Izzo, R Capasso and F Capasso: Eating garlic and onion: a matter of life or death. British Journal of Cancer2004; 91:194.

Surjushe A, Vasani R, Saple DG: Aloe vera: a short review. Indian J Dermatol2008;53(4):163-6.

Furukawa F, Nishikawa A, Chihara T, Shimpo K, Beppu H, Kuzuya H, et al. Chemopreventive effects of Aloe arborescens on N-nitrosobis (2-oxopropyl) amine-induced pancreatic carcinogenesis in hamsters. Cancer Lett2002;178:117–22.

Fenig E, Nordenberg J, Beery E, Sulkes J, Wasserman L. Combined effect of aloe-emodin and chemotherapeutic agents on the proliferation of an adherent variant cell line of Merkel cell carcinoma. Oncol Rep2004;11:213–7.

Garnick JJ, Singh B, Winkley G. Effectiveness of a medicament containing silicon dioxide, aloe, and allantoin on aphthous stomatitis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod1998;86:550–6.

Su K, Mehta V, Ravikumar L, Shah R, Pinto H, Halpern J, et al. Phase II double-blind randomized study comparing oral aloe vera versus placebo to prevent radiation-related mucositis in patients with head-and-neck neoplasms. Int J Radiat Oncol Biol Phys2004;60:71–7.

Bosley C, Smith J, Baratti P. A phase III trial comparing an anionic phospholipid-based (APP) cream and aloe vera-based gel in the prevention and treatment of radiation dermatitis. Int J Radiat Oncol Biol Phys2003;57:S4–38.

Garnick JJ, Singh B, Winkley G: Effectiveness of a medicament containing silicon dioxide, aloe, and allantoin on aphthous stomatitis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod1998;86(5): 550-6.

Feily A, Namazi MR. Aloe vera in dermatology: a brief review. Ital Dermatol Venereol2009;144:85-91.

Lee SS, Zhang W, Li Y. The antimicrobial potential of 14 natural herbal dentifrices: results of an in vitro diffusion method study. J Am Dent Assoc2004;135(5):1133-41.

Villalobos OJ, Salazar CR, Sánchez GR. Efecto de un enjuague bucal compuesto de aloe vera en la placa bacteriana e inflamación gingival. Acta Odontol Venez2001;39(2):16-24.

Shukla Y, Singh M Cancer preventive properties of ginger: a brief review. Food Chem Toxicol2007; 45(5):683-90.

Kuo JM, Yeh DB, Pan BS: Rapid photometric assay evaluating antioxidative activity in edible plant material. Journal of Agricultural & Food Chemistry 1999; 47:3206-3209.

Reddy AC, Lokesh BR: Studies on spice principles as antioxidants in the inhibition of lipid peroxidation of rat liver microsomes. Mol Cell Biochem1992; 111:117-124.

Krishnakantha TP, Lokesh BR: Scavenging of superoxide anions by spice principles. Indian Journal of Biochemistry & Biophysics 1993;30:133-134.

Ahmed RS, Seth V, Banerjee BD: Influence of dietary ginger (Zingiber officinales Rosc) on antioxidant defense system in rat: comparison with ascorbic acid. Indian Journal of Experimental Biology2000;38:604-606.

Banerjee S, Bueso-Ramos C, Aggarwal BB: Suppression of 7,12- dimethylbenz(a)anthracene-induced mammary carcinogenesis in rats by resveratrol: role of nuclear factor-kappa B, cyclooxygenase 2, and matrix metalloprotease9. Cancer Res2002, 62:4945-4954.

Sekiwa Y, Kubota K, Kobayashi A: Isolation of novel glucosides related to gingerdiol from ginger and their antioxidative activities. Journal of Agricultural & Food Chemistry2000;48:373-377.

Grzanna R, Lindmark L, Frondoza CG: Ginger – an herbal medicinal product with broad anti-inflammatory actions. J Med Food2005;8:125-132.

Lantz RC, Chen GJ, Sarihan M, Solyom AM, Jolad SD, Timmermann BN: The effect of extracts from ginger rhizome on inflammatory mediator production. Phytomedicine 2006.

Jolad SD, Lantz RC, Chen GJ, Bates RB, Timmermann BN: Commercially processed dry ginger (Zingiber officinale): composition and effects on LPS-induced PGE2 production. Phytochemistry 2005;66:1614-1635.

Jolad SD, Lantz RC, Solyom AM, Chen GJ, Bates RB, Timmermann BN: Fresh organically grown ginger (Zingiber officinale): composition and effects on LPS-induced PGE2 production. Phytochemistry 2004;65:1937-1954.

Shukla Y, Singh M: Cancer preventive properties of ginger: A brief review. Food Chem Toxicol 2006.

Ahmad N, Katiyar SK, Mukhtar H: Antioxidants in chemoprevention of skin cancer. Current Problems in Dermatology 2001;29:128-139.

Katiyar SK, Agarwal R, Mukhtar H: Inhibition of tumor promotion in SENCAR mouse skin by ethanol extract of Zingiber officinale rhizome. Cancer Research1996;56:1023-1030.

Surh Y: Molecular mechanisms of chemopreventive effects of selected dietary and medicinal phenolic substances. Mutation Research1999;428:305-327.

Manju V, Nalini N: Chemopreventive efficacy of ginger, a naturally occurring anticarcinogen during the initiation, post-initiation stages of 1,2 dimethylhydrazine-induced colon cancer. Clin Chim Acta2005;358:60-67.

Aktan F, Henness S, Tran VH, Duke CC, Roufogalis BD, Ammit AJ: Gingerol metabolite and a synthetic analogue Capsarol inhibit macrophage NF-kappaB-mediated iNOS gene expression and enzyme activity. Planta Med2006;72:727-734.

Takada Y, Murakami A, Aggarwal BB: Zerumbone abolishes NF kappa Band I kappa B alpha kinase activation leading to suppression of antiapoptotic and metastatic gene expression, upregulation of apoptosis, and down regulation of invasion. Oncogene2005; 24:6957-6969.

Kim SO, Chun KS, Kundu JK, Surh YJ: Inhibitory effects of [6]-gingerol on PMA-induced COX-2 expression and activation of NF-kappaB and p38 MAPK in mouse skin Biofactors2004;21:27-31.

Kim SO, Kundu JK, Shin YK, Park JH, Cho MH, Kim TY, Surh YJ: [6]- Gingerol inhibits COX-2 expression by blocking the activation of p38 MAP kinase and NF-kappa B in phorbol ester stimulated mouse skin. Oncogene2005;24:2558-2567.

Nonn L, Duong D, Peehl DM: Chemopreventive anti-inflammatory activities of curcumin and other phytochemicals mediated by MAP kinase phosphatase-5 in prostate cells. Carcinogenesis 2006.

Kim EC, Min JK, Kim TY, Lee SJ, Yang HO, Han S, Kim YM, Kwon YG: [6]-Gingerol, a pungent ingredient of ginger, inhibits angiogenesis in vitro and in vivo. Biochem Biophys Res Commun2005; 335:300-308.

Park M, Bae J, Lee DS. Antibacterial activity of [10]-gingerol and [12]-gingerol isolated from ginger rhizome against periodontal bacteria. Phytother Res2008;22:1446-9.

Krishnaswamy K. Traditional Indian spices and their health significance. Asia Pac J Clin Nutr2008;17:265-8.

Chattopadhyay I, Biswas K, Bandyopadhyay U, Banerjee RK: Turmeric and curcuminBiological actions and medicinal applications. Curr Sci2004; 87:44-50.

Aggarwal BB, Sundaram C, Malani N, Ichikawa H: Curcumin: The Indian solid gold. Adv Exp Med Biol 2007;595:1-75.

Ammon HP, Wahl MA: Pharmacology of Curcuma longa. Planta Med1991; 57:1-7.

Aggarwal BB, Kumar A, Bharti AC: Anticancer potential of curcumin: preclinical and clinical studies. Anticancer Res2003; 23:363-398.

Sreejayan Rao MN: Curcuminoids as potent inhibitors of lipid peroxidation. J Pharm Pharmacol 1994; 46:1013-1016.

Brennan P, O’Neill LA: Inhibition of nuclear factor kappaB by direct modification in whole cells: Mechanism of action of nordihydroguaiaritic acid, curcumin and thiol modifiers. Biochem Pharmacol 1998; 55:965-973.

Jobin C, Bradham CA, Russo MP, Juma B, Narula AS, Brenner DA, Sartor RB: Curcumin blocks cytokine-mediated NF-kappa B activation and proinflammatory gene expression by inhibiting inhibitory factor I-kappa B kinase activity. J Immunol1999;163:3474-3483.

Wang D, Veena MS, Stevenson K, Tang C, Ho B, Suh JD, Duarte VM, Faull KF, Mehta K, Srivatsan ES, Wang MB: Liposome-encapsulated curcumin suppresses growth of head and neck squamous cell carcinoma in vitro and in xenografts through the inhibition of nuclear factor kappaB by an AKT-independent pathway. Clin Cancer Res2008;14: 6228-6236.

Mohandas KM, Desai DC: Epidemiology of digestive tract cancers in India. V. Large and small bowel. Indian J Gastroenterol1999;18:118-121.

Krishnaswamy K, Goud VK, Sesikeran B, Mukundan MA, Krishna TP: Retardation of experimental tumorigenesis and reduction in DNA adducts by turmeric and curcumin. Nutr Cancer 1998; 30:163-166.

Inano H, Onoda M, Inafuku N, Kubota M, Kamada Y, Osawa T, Kobayashi H, Wakabayashi K: Chemoprevention by curcumin during the promotion stage of tumorigenesis of mammary gland in rats irradiated with gamma-rays. Carcinogenesis1999; 20:1011-1018.

Collett GP, Robson CN, Mathers JC, Campbell FC: Curcumin modifies Apc (min) apoptosis resistance and inhibits 2-amino 1-methyl-6- phenylimidazo[4,5-b]pyridine (PhIP) induced tumour formation in Apc (min) mice. Carcinogenesis 2001; 22:821-825.

Khafif A, Lev-Ari S, Vexler A, Barnea I, Starr A, Karaush V, Haif S, Ben-Yosef R: Curcumin: a potential radio-enhancer in head and neck cancer. Laryngoscope 2009;119:2019-2026.

K. M. Mohandas and D. C. Desai, “Epidemiology of digestive tract cancers in India. V. Large and small bowel,” Indian Journal of Gastroenterology1999;18: 118–121.

Jacob A, Wu R, Zhou M,Wang P Mechanism of the Anti-inflammatory Effect of Curcumin: PPAR-γ Activation PPAR Research2007; Article ID 89369.

Chen D, Nie M, Fan MW, Bian Z. Anti-inflammatory activity of curcumin in macrophages stimulated by lipopolysaccharides from Porphyromonas gingivalis. Pharmacology2008; 82:264-9.

Kim JE, Kim HE, Hwang JK, Lee HJ, Kwon HK, Kim BI. Antibacterial characteristics of Curcuma xanthorrhiza extract on Streptococcus mutans biofilm. J Microbiol2008;46:228-32.

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