Fulfilling the Promises: Contribution of Genomes for the Changing Dentistry

Ajay Bhambal, Sudhanshu Saxena, Manish Jain, Aishwarya Singh

Abstract


Genome contains all the biological information needed to build and maintain an organism. The mapping of human genes is a crucial step in the development of various aspects of health care, including dentistry. The human genome project, have recently opened immense opportunities for transformation of basic science discoveries to oral health care at the chair side through clinical research. This review aimed to summarize its implications in dentistry.

 


Keywords


Genome; Dentistry; Human Genome Project

References


Garcia.I, Tabak.L.A. A view of the future: dentistry and oral health in America. The Journal of the American Dental Association. 2009;140(suppl 1):44S-8S.

Wright.J, Hart.T. The genome projects: implications for dental practice and education. Journal of Dental Education. 2002;66(5):659-71.

Yanase.T. Human genetics: Past, present, and future, with special reference to major trends in Japan. Journal of Human Genetics. 1997;42(2):265-316.

Kuo.WP, Whipple.ME, Jenssen.TK, Todd.R, Epstein JB, Ohno-Machado.L, et al. Microarrays and clinical dentistry. The Journal of the American Dental Association. 2003;134(4):456-62.

Slavkin.HC. The human genome, implications for oral health and diseases, and dental education. Journal of Dental Education. 2001;65(5):463-79.

Collins.FS, Patrinos.A, Jordan.E, Chakravarti.A, Gesteland.R, Walters.LR. New goals for the US human genome project: 1998-2003. Science. 1998;282(5389):682.

Jeffcoat.MK. A clearing in the forest: The wondrous genome. The Journal of the American Dental Association. 2004;135(6):692.

Sharpe.PT. Homeobox genes and orofacial development. Connective Tissue Research. 1995;32(1-4):17-25.

Vastardis H, Karimbux N, Guthua SW, Seidman J, Seidman CE. A human MSX1 homeodomain missense mutation causes selective tooth agenesis. Nature genetics. 1996;13(4):417-21.

Stockton.DW, Das.P, Goldenberg.M, D'Souza.RN, Patel PI. Mutation of PAX9 is associated with oligodontia. Nature Genetics. 2000;24(1):18-20.

Witkop.Jr.C. Amelogenesis imperfecta, dentinogenesis imperfecta and dentin dysplasia revisited: problems in classification. Journal of Oral Pathology & Medicine. 1988;17(9 10):547-53.

Bäckman B, Holmgren G. Amelogenesis imperfecta: a genetic study. Human Heredity. 1988;38(4):189-206.

Shields E. A new classification of heritable human enamel defects and a discussion of dentin defects. Birth defects original article series. 1983;19(1):107-27.

Prockop DJ, Kuivaniemi H, Tromp G. Molecular basis of osteogenesis imperfecta and related disorders of bone. Clinics in Plastic Surgery. 1994;21(3):407-13.

Pallos D, Hart P, Cortelli J, Vian S, Wright J, Korkko J, et al. Novel COL1A1 mutation (G599C) associated with mild osteogenesis imperfecta and dentinogenesis imperfecta. Archives of Oral Biology. 2001; 46(5): 459-70.

Dean JA, Hartsfield Jr JK, Wright JT, Hart TC. Dentin dysplasia, type II linkage to chromosome 4q. Journal of Craniofacial Genetics and Developmental Biology. 1997;17(4):172-7.

Gunsolley J, Pandey J, Quinn S, Tew J, Schenkein H. The effect of race, smoking and immunoglobulin allotypes on IgG subclass concentrations. Journal of Periodontal Research. 1997;32(4):381-7.

Hart TC, Kornman KS. Genetic factors in the pathogenesis of periodontitis. Periodontology 2000. 1997;14(1):202-15.

Hart TC. Applications of molecular epidemiology to head and neck cancer. Otolaryngologic Clinics of North America. 1997;30(1):21-34.

Bindhu O, Ramadas K, Sebastian P, Pillai MR. High expression levels of nuclear factor kappa B and gelatinases in the tumorigenesis of oral squamous cell carcinoma. Head & ck. 2006;28(10):916-25.

Lee JI, Soria JC, Hassan KA, El-Naggar AK, Tang X, Liu DD, et al. Loss of PTEN expression as a prognostic marker for tongue cancer. Archives of Otolaryngology Head and Neck Surgery. 2001; 127 (12):1441-5.

Störkel S, Reichert T, Reiffen K, Wagner W. EGFR and PCNA expression in oral squamous cell carcinomas--a valuable tool in estimating the patient's prognosis. European journal of cancer Part B, Oral Oncology. 1993;29(4):273-7.

Anderson JA, Irish JC, McLachlin CM, Ngan BY. H-ras oncogene mutation and human papillomavirus infection in oral carcinomas. Archives of Otolaryngology- Head and Neck Surgery. 1994;120 (7):755-60.

Munger K, Baldwin A, Edwards KM, Hayakawa H, Nguyen CL, Owens M, et al. Mechanisms of human papillomavirus-induced oncogenesis. Journal of Virology. 2004;78(21):11451-60.

Geisler SA, Olshan AF. GSTM1, GSTT1, and the risk of squamous cell carcinoma of the head and neck: a mini-HuGE review. American journal of epidemiology. 2001;154(2):95-105.

Han XM, Zhou HH. Polymorphism of CYP450 and cancer susceptibility. Acta Pharmacol Sin. 2000; 21(8):673-79.

Clark RAF. Cutaneous tissue repair: Basic biologic considerations. Journal of the American Academy of Dermatology. 1985;13(5):701-25.

Galeano M, Altavilla D, Cucinotta D, Russo GT, Calò M, Bitto A, et al. Recombinant human erythropoietin stimulates angiogenesis and wound healing in the genetically diabetic mouse. Diabetes. 2004;53 (9): 2509-17.

Ashcroft GS, Yang X, Glick AB, Weinstein M, Letterio JJ, Mizel DE, et al. Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response. Nature Cell Biology. 1999;1 (5) :260-6.

Hamilton J. Dental implications of the human genome project 2001. Available from: http://www.cda.org/Library/cda_member/pubs/journal/jour0101/genome.html.


Full Text: PDF

Refbacks

  • There are currently no refbacks.




Index Copernicus Index Copernicus Google Scholar NISCAIR OpenJGateDOAJUlrichsWeb
line
System Developed By Stanford University Arizona State University Simon Fraser University Canadian Centre For Studies In Publishing University of British Columbia - Faculty of Education
W3C XHTML v1.0 Verified W3C verified Valid CSS v2.1 PHP5 Enabled CopyScape Protected Made On Mac Apache Enabled MySQL Powered
Published by Celesta Software Pvt Ltd